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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability

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Xiong Y, Huang H, Chen F, Tang Y (2023) CircDLGAP4 induces autophagy and improves endothelial cell dysfunction in atherosclerosis by targeting PTPN4 with miR-134-5p