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Description

It was originally described as an endemic disorder in the Chuvash region of Russia, and has since been found as an endemic disorder in the island of Ischia and as a sporadic disorder in other locations and ethnic groups

Science 220, 10551057

Martof, 1956b)

Its natural to gradually lose collagen and elastin with age, though certain lifestyle habits such as smoking and excessive sun exposure can increase the rate of loss