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The physiological abnormalities were represented in the Li 2 CO 3 -injected group by obscuring 2 normal bands

The impaired cross-talk between dysfunctional endothelial cells and fibroblasts further compromises angiogenesis, as endothelial cells provide critical paracrine signals (such as PDGF-BB) that recruit and activate fibroblasts, while fibroblasts produce VEGF and deposit the ECM scaffold necessary for endothelial tube formation