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What we are reporting is that the pattern is consistent enough across our patient population to make us think the combination is worth considering in carefully selected cases, while acknowledging that we cannot yet quantify the effect with the rigour that randomized trial evidence would provide

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While all studies adequately ascertained exposure and ensured comparability between outcome groups by controlling for confounders, 42% (n = 5) did not provide adequate sample representativeness and size, and 17% (n = 2) did not report the non-response rate