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Further, accumulation of SAMe could lead to an elevated level of Hcy, which can then be catalyzed by methionyltRNA synthetase (MetRS) to form lysine-reactive metabolite Hcy thiolactone (1)

Arch Med Res 38:948 Raftos JE, Whillier S, Kuchel PW (2010) Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data

Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line