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Simply put, glutamate is the "gas pedal" of the brain and body

doi: 10.1038/84635 68 PaderaTPKadambiADi TomasoEMouta CarreiraCBrownEBBoucherYet al

Neural Regeneration Research, 10(4), 629636

A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)