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This variant leads to an amino acid substitution that may impair enzyme activity and alter local T3 availability, particularly in the brain and pituitary

Control 10, 5

PKG: Protein kinase-G POD: Peroxidase PLP: Pyridoxal 5-phosphate ROS: Reactive oxygen species SAG: Senescence-activated promoter SAM: S-adenosyl-methionine SOD: Superoxide dismutase SSA: Succinic semi-aldehyde SSADH: Succinic semi-aldehyde dehydrogenase SSR: Succinic semi-aldehyde reductase References Abd Elbar OH, Elkelish A, Niedbaa G et al (2021) Protective effect of -aminobutyric acid against chilling stress during reproductive stage in tomato plants through modulation of sugar metabolism, chloroplast integrity, and antioxidative defense systems

They were Adolf Jarisch and Karl Herxheimer, respectively, and this phenomenon became known as a Jarisch Herxheimer reaction

If we remove the methionine input in the model, the GSH concentration declines to a new steady-state 47% of normal