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The IR usually progresses in silence and manifests clinically years after being present in the form of hyperglycemia, favoring atherogenesis and plaque progression in a curvilinear relationship with vascular disease, even in the absence of hyperglycemia ( 2 O 2 and O 2 activate stress-sensitive serine/threonine kinases such as JNK, IKK, and PKC, which phosphorylate IRS-1 at inhibitory serine residues (Ser307, Ser612), disrupting its interaction with the insulin receptor and promoting proteasomal degradation (Roden et al., 2017)

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Obesity is a major public health problem in the United States and many other countries because of its high and increasing prevalence, adverse effects on cardiometabolic function, causal relationship with serious diseases, and economic consequences due to increased health care costs and loss of work

Our study shows that the complete absence of food triggers a defensive response in CAT and elevates it to statistical significant levels

Exercise regularly, seek counselling, and employ relaxation techniques to lessen the impact of heart palpitations resulting from stress