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TAFs can play a role in hypoxic conditions to secrete TGF-2 and HIF-1, which can activate hedgehog transcription factor GLI2 expression and confer resistance to FOLFOX (5-FU and oxaliplatin) (54)

I think that is common

Although no site-specific ADCs are found in the current eleven FDA-approved products (Adcetris , Besponsa , Blenrep [initiating the process for market withdrawal], Enhertu , Kadcyla , Mylotarg , Padcev , Polivy , Tivdak , Trodelvy , Zynlonta ), their TAA-targeting antibody scaffolds can presumably be further engineered for multi-payload conjugations to achieve better drug efficacy by utilizing the abovementioned site-specific conjugation technologies

Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide

Central DP compromises on security, by requiring a potentially hackable curator to serve as custodian of the data from multiple hospitals, to be able to answer queries in a DP manner