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Although speculative, it could be hypothesised that this proposed increase in susceptibility of OPCs to ROS-induced damage compared to other brain cell types could, at least in part, be driven by ROS induced alterations in DNA methylation in these cells [6, 30, 32]

Moreover, prebiotics administration in PD patients helps in restoration of gut microbial diversity, which often reduced due to dysbiosis in GM (113)

TAMs are characterized by elevated glutamine utilization, which is reflected by their high expression of both glutamine transporters and catabolic enzymes 43,44

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