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In addition, the mRNA abundances of mitochondrial Acc2 isoform, which is found highly enriched in oxidative tissues such as skeletal muscle and heart 15 , of long-chain acetyl-CoA dehydrogenase ( Acadl ), which catalyses the initial step of mitochondrial fatty acid oxidation, of the endoplasmic reticulum-located Cpt1c and of mitochondrial trifunctional protein ( Mtp ) that is functionally responsible for electron transfer from mitochondrial long-chain fatty acids to mitochondrial respiratory complexes I (CI) and III (CIII) 16 , were found to be higher in astrocytes versus neurons (Supplementary Fig