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After binding to PLP, H241 rotated to the position adjacent to the PLP pyridine ring

doi: 10.1016/j.cmet.2016.06.004 133 ChenXJinJChangRYangXLiNZhuXet al

The initiating event involves Ca 2+ homeostasis disruption leading to intracellular Ca 2+ overload

N.JiH.XiaoZ

In one study involving 6,455 treatment courses of acetylcysteine, it doesnt seem that there was any serious harm from anaphylactoid reactions (e.g., death)