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Bernaerts S, Boets B, Steyaert J, Wenderoth N, Alaerts K

In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

To do so, measured M concentration of target metabolite in the erythrocyte fraction was divided on concentration factor after gradient

Planta 133:2125 Foyer CH, Noctor G (2005a) Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses

Neuropsychopharmacology 34 , 13631380 (2009)