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Tom20 senses iron-activated ros signaling to promote melanoma cell pyroptosis

Transient stress or increased cytoplasmic TDP-43 triggers phase separation into toxic cytoplasmic droplets that block nuclear import, deplete nuclear TDP-43, and cause cell death, offering a present mechanistic model for ALS/FTD pathology (Gasset-Rosa et al., 2019)

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Although the majority of the bodys cells use glutathione to protect themselves from oxidative stress, different types of cells need slightly different quantities of glutathione

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