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doi: 10.3389/fvets.2025.1558440 Received 13 January 2025 Accepted 05 May 2025 Published 05 June 2025 Volume 12 - 2025 Edited by Moyosore Joseph Adegbeye, University of Africa, Nigeria Reviewed by Can Yang, Hengyang Normal University, China Fuquan Yin, Guangdong Ocean University, China Updates Copyright 2025 Qu, Sun, Liang, Nie, Gao, Yuan, Wang and Zhou

C.LoTempioJ.AyanyanS.CarrieJ.et al (2019)

Given the importance of H2AX ubiquitination in triggering the DDR, several hydrolases have been shown to regulate the ubiquitination cascade directly or indirectly

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This signaling not only upregulates anti-apoptotic proteins such as Bcl-2 but also stimulates the secretion of IL-6, reinforcing an autocrine and paracrine loop that sustains inflammation and tumor growth [126]