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This chronic inflammatory state heavily impacts the cardiovascular system

296,297 Collectively, these enzymes facilitate the ubiquitylation of protein substrates, a process critical for targeting proteins for degradation

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Murray PE, Farber RM, Namerow KN, Kuttler S, Garcia-Godoy F

Protein turnover in the regulation of adipocyte lipolysis The degradation of proteins is an essential cellular function necessary for protein quality control and maintaining protein composition of organelles