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The acute response initiation involves changes in blood flow stimulated by prostaglandin E2 and prostaglandin I2, while leukotriene B4, produced from arachidonic acid, stimulates the recruitment of polymorphonuclear leukocytes

Among them, the cGAS-STING signaling pathway plays a dual role in tumor immunity: it can suppress anti-tumor immunity to promote cancer progression, or enhance tumor antigen presentation to exert an anti-tumor effect

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Besides potentiating the expression of Cx43, exposure to -amyloid opens Cx43 hemichannels, as shown by ethidium bromide uptake assay 489,490