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Description

Peripheral nerve involvement in spinocerebellar ataxias

Remarkably, despite the rapid depletion of mitochondrial cysteine under starved conditions, Fe-S cluster synthesis persisted in support of respiratory function through the onset of ferroptosis

Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study

Rarely reported side effects include: Allergic reactions, leading to a rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing