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Downstream of the receptors, the phosphatidylinositol-3-kinase (PI3K)-Akt and mitogen-activated protein kinase (MAPK) are candidate signalling pathways that mediate FASN expression through the sterol regulatory element-binding protein 1c (SREBP-1c)

PMID: 157 GernezEDeheulSTardCJoncquelMDouillardCGrzychG

When ferroptosis occurs, ferrous ions will start liposome peroxidation through Fenton reaction, which will lead to the accumulation of ROS in cells, thus it is easier to induce strong ERS

Bayley EM, Zhou N, Mitchell KG, Antonoff MB, Mehran RJ, Rice DC, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Cinciripini PM, Karam-Hage M, Roth JA, Hofstetter WL

Interestingly, -tocopherol is being increasingly appreciated to have a better potential than -tocopherol [52]