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Hyperpigmentation can be the result of medication, pregnancy, and spending too long in direct sunlight (as UV radiation triggers melanin production)

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For example, a study in 24 older adults supplemented with 300 mg/day of coenzyme Q 10 or placebo for at least seven days prior to cardiac surgery found that the coenzyme Q 10 content of atrial tissue was significantly increased in those taking coenzyme Q 10 , especially in patients greater than 70 years of age (38)