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N.MostofaM

Mean Depakote doses for completers in this study were 1,118, 1,525, and 2,402 mg/day at Days 7, 14, and 21, respectively

( f ) Acetyl-CoA abundance was assessed in cells transduced with shRNA targeting TMLHE with or without supplementation with the indicated doses of acetate (n = 8 technical replicates representative from 2 independent experiments)

These higher dosages are typically for treating deficiencies rather than for ongoing maintenance

Results: The native LMN breath concentrations over 1.50 ppbv significantly discriminated patients with SLD compared to CTRL (p =0.003, AUROC 0.87, Se 75%, Sp 84%, PPV 0.96, NPV 0.71)