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In dental and maxillofacial contexts, the resilience of the multi-species oral microbiome often leads to rapid re-colonization, challenging the long-term efficacy of single-use nanorobotic disinfection strategies ( 3.5 Neurosurgical and orthopedic applications Neurosurgery and orthopedic surgery demand exceptional operative precision, driving the evolution of nanorobotics toward micromanipulation at the tissue and cellular levelsincluding micro-scale suturing, grasping, and cutting ( in vitro , and the feasibility and preliminary biological safety were verified in ex vivo pig brain and in vivo animal models (Figure 6A)