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Such TBI-induced actions, whether occurring early or later in life, can readily increase the vulnerability of the brain to other neurodegenerative events as detailed in the two hit hypothesis of the Latent Early-life Associated Regulation (LEARn) model of Lahiri et al., [92, 93], whereby genetic and environmental risk factors combine in an epigenetic pathway to trigger the etiology of a later neurobiological disorder (such as TBI leading to AD)

Firstly, the quintessential strength of TCM lies in its holistic regulation and personalized treatment based on syndrome differentiation

Thus, in vitro Notch overexpression or PDX models are unsuitable for testing our hypothesis that RSL3 targets the astrocyte-like state

We hypothesize that targeting SIRT7 might be beneficial for treating EGF signaling-dependent cancers, e.g., triple-negative breast cancers with increased EGFR expression and activity, colorectal and pancreatic cancers that harbor Ras mutations and NSCLCs with EGFR mutations

These findings suggest that further investigation into the mechanisms by which IL-6 influences ALD is necessary