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Although its use was previously discouraged because of concerns about lactic acidosis, contemporary data indicate that this risk is minimal with appropriate renal and hepatic monitoring (Rahman and Tuba, 2022

The 1.53 M concentrations of SERF2 that allow phase separation in the presence of rG4s are below the SERF2 concentrations present in human cells which range from ~7 M in U2OS cells to ~23 M in MCF7 breast cancer cells 61

SLC25A12, SLC25A13, GOT1, and GOT2 levels increased with aging in the cerebral cortex, hippocampus, and cerebellum, while MDH2 levels increased with aging in the cerebral cortex and hippocampus ( To synthesize one molecule of the 16:0 fatty acid palmitate, 14 NADPH molecules are oxidized, while to synthesize one molecule of cholesterol, 18 to 19 molecules of NADPH are oxidized (Vance and Vance, 1996)