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According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness

If your levels were very low, the change can feel more obvious during those first couple of days

Still, side effects from B12 supplements are possible, especially at higher doses, and include: Headache Nausea Vomiting Fatigue Weakness Diarrhea Tingling in the hands and feet Nasal spray Vitamin B12 is also available in a nasal spray

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There is no recommended maximum