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Moreover, single-nucleus RNA sequencing of postmortem ALS spinal cords identified glial populations enriched for inflammatory and activation-associated markers, many of which converge on RIPK1 signaling and necroptotic cell death pathways (Zelic et al., 2025)

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Deficiencies in zinc have been observed in some women with PCOS, and it has been hypothesized that this may contribute to the insulin-resistant phenotype of the condition