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What is worth to summarize here is the fact that several pro-apoptotic stimuli induce an early extrusion of GSH from cells leading to a widespread mitochondrial damage and to cytochrome c release into the cytosol, the starting condition for apoptotic intrinsic pathway commitment

Etemad-Moghadam, S., Alaeddini, M., Mousavi, R

Astrocytes supply GSH precursors to neurons, enabling detoxification of ROS generated during high metabolic activity (44, 47)

Safety and antitumor activity of the multitargeted pan-TRK, ROS1, and ALK inhibitor entrectinib: combined results from two phase I trials (ALKA-372-001 and STARTRK-1)

Buchon N, Silverman N, Cherry S (2014) Immunity in drosophila melanogaster from microbial recognition to whole-organism physiology