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(Wang et al., 2021) found that XIST and HOTAIR are long non-coding RNAs (lncRNAs) with significantly elevated expression in the serum of patients with osteoporosis, and that XIST and HOTAIR acted as ceRNAs (competing endogenous RNAs) to upregulate NNMT expression by adsorbing miR-29b-respectively

Additional research demonstrates that it can directly target adipose tissue, increasing fat breakdown (lipolysis) and reducing fat cell formation (lipogenesis), especially in regions where stubborn fat deposits are common

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Metabolic syndrome However, Mouse models showed higher energy expenditure, increased fatty-acid oxidation, reduced fat-mass accumulation, and improved insulin sensitivity