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Results Inhibition of Glutathione Metabolism Depletes Neuronal Glutamate and Affects Excitatory Transmission

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Exercise capacity, measured by the 6-minute walk test, showed that 50% of ARA-290 patients could walk at least 25 meters more compared with only 12% of placebo patients

In the coming decades, the challenges in the field of T21 will involve not only identifying effective therapies to mitigate cognitive defects but also understanding the molecular and cellular mechanisms underlying the characteristic phenotype resulting from genetic triplication