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For instance, it was observed that mmachc shares 51% sequence identity with the human protein but differs at the C-terminus, resulting in a shorter protein (250 amino acids in zebrafish versus 282 amino acids in humans)

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This must tax regulatory systems that prevent abnormal redox cycling of iron, such as the Fe 2+ -glutathione complexes thought to be the dominant form of iron in the cellular labile iron pool (Berndt and Lillig, 2017