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We believe clarifying this information addresses, in part, commenters' requests for CMS to provide transparency around the type of information CMS will request from ACOs as part of the reopening request process, and to address concerns over whether the information CMS may request would be readily available to ACOs

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Fan T, Jiang WL, Zhu J, Feng ZY

By precisely controlling gene expression involving hormone precursors, receptors, and transcriptional regulators, these ncRNAs within the HPG axis influence the production and release of important hormones, such as gonadotropin-releasing hormone (GnRH) from the hypothalamus and LH and follicle-stimulating hormone (FSH) from the pituitary

Coadministration with anti-OX40 antibodies further amplified T-cell responses and enhanced tumor regression, underscoring the potential of Mann-NCs as a self-adjuvanted immunomodulatory nanoplatform that bridges PRR-mediated innate sensing with adaptive antitumor immunity