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In a study on breast cancer, ALA-treated MDA-MB-231 and 4T1 breast cancer cell lines both exhibited downregulated expression of EMT markers such as Snail, vimentin, and Zeb1, along with impaired cell migration capabilities [73]

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Txn1, Ctsd and Cdk4 are key proteins of combination therapy with taurine, epigallocatechin gallate and genistein against liver fibrosis in rats

Thus the discovery of cuproptosis reveals that the targets and pathways involved in Cu-dependent cell death are highly correlated with mitochondrial respiration proteins, showing increasing expect for drug discovery

Urgent research is required to identify synergistic combinations (e.g., FSP1 inhibitors with GPX4 inhibitors, ferroptosis inducers with IDO1/m6A inhibitors, and ferroptosis inducers with immune checkpoint blockade) that can simultaneously bypass multiple resistance pathways across diverse GBM subclones