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If the change calculated is more than a 100% increase or 50% decrease in either V or CL, the assumptions made about the timing of the sample and the dosing history should be critically examined

In vivo experiments of prion-disease model mice showed cytotoxicity of PERK-dependent reactive astrocytes against neurons

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6.1 mtDNA as a biomarker for ART toxicity, metabolic complications, and immunological failure Quantifying mtDNA damage provides a mechanistic insight into ART-related toxicities and may support personalized management