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MDA reacts with thiobarbituric acid (TBA) to generate the MDA-TBA adduct which can be quantified colorimetrically by a spectrophotometer (OD 532 nm)

Cystine is subsequently converted to cysteine and synthesized into glutathione (GSH) by glutamate cysteine ligase (GCL) and glutamylcysteine synthetase (GCS), which defines GPX4 activity[52, 53]

Notably, an IG-CDR-based peptide designed to disrupt MIF-CD74 signaling has been shown to reduce the accumulation of M-MDSCs in metastatic melanoma lesions [136]

As shown in Figure 3B, the TAU uptake activity increased in a time-dependent manner from 0 to 36 h and reached a plateau after 36 h

Ahdoot from the University of Michigan for his research on this topic and his editing of this manuscript