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doi: 10.1084/jem.20231954 14 WangTWNakanishiM

Finley, L

Experimental results demonstrated that AI alleviates diabetes-associated cognitive impairment through dual mechanisms: activating the Kelch-like ECH-associated protein (Keap1)/nuclear factor-erythroid-derived related factor 2 (Nrf2) signaling pathway to exert antioxidant effects, and inhibiting the TLR-4/nuclear factor-kappa B (NF-B) signaling pathway to mitigate neuroinflammation, thereby improving cognitive dysfunction and hyperglycemia