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To replace TrxR1 Cys497 and Sec498 with Ser, the forward primer was 5-GAC ATC CTC CAG TCT GGC TCC TCC GGT TAA GCC-3, and the reverse primer was 5-CCA CAC TGG GGC TTA ACC GGA GGA GCC AGA-3

doi:10.1038/cdd.2009.107 Savaskan NE, Borchert A, Bruer AU, Kuhn H (2007) Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury