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Description

NNMT Inhibitors are Selective and do not Impact Related Methyltransferases or Enzymes in the NAD+ Salvage Pathway

By attenuating NNMT activity, 5Amino1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)