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TRANSSULFURATION SUPPORTS GOT1/2 DEFICIENT TUMOR GROWTH AND REPRESENTS A TARGETABLE VULNERABILITY IN CANCER In contrast to defined in vitro conditions, the tumor microenvironment provides multiple redox-modifying substrates

Antioxidants inhibit the formation of free radicals or mitigate their damaging effects by: (1) acting as an alternative substrate for oxidation, thereby preventing an oxidation reaction which would lead to the formation of free radicals, (2) directly scavenging free radicals, or (3) indirectly preventing the development of oxidant compounds by either upregulating antioxidant defenses or inhibiting free radical production [27]

Early studies have shown that continuous subcutaneous injection of MG (0.2 mL/dose, 10 mg/mL twice a week for 10 weeks) induced tumor formation in rats, with a tumorigenicity rate of 22.22% ( Figure 2 Table 1 The pro-cancer manifestations of MG/AGEs in vivo and in vitro