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A 1994 in vivo study by Natera, Jiang, and Ng extended the observation into a whole animal, reporting that chronic administration of synthetic hGH 177 to 191 to genetically obese (ob/ob) mice was associated with reduced cumulative body-weight gain and reduced adipose mass relative to controls [2]

BPC also upregulates growth hormone receptors on all the cells

Compounds were initially tested for NNMT inhibition activity at 100 M or 1 mM concentration (compounds with no activity at 100 uM were tested at 1 mM concentration)

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