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Nevertheless, advances in neuroimaging, biomarker analysis, and longitudinal cohort studies have enabled researchers to corroborate key mechanistic pathways in humans, particularly those involving neurotrophic deficits, hippocampal atrophy, and neurotransmitter dysregulation

24 These mutations serve as key molecular discriminators between glioma subtypes and are highly prevalent in lower-grade diffuse gliomas (WHO grades IIIII) and secondary GBMs 25 but are largely absent in primary GBMs, which are predominantly IDH wild-type

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KPV, a tripeptide derived from ?-MSH, is researched for its anti-inflammatory properties via melanocortin receptor pathways

Am J Pathol 179(3):136072 Braidy N et al (2009) Effects of kynurenine pathway metabolites on intracellular NAD synthesis and cell death in human primary astrocytes and neurons