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Description

J Clin Med 11:4629

KochMDeKoskySTGoodmanMSunJFurtadoJDFitzpatrickALet al

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Mechanistically, autoantibodies and interferon- present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREM to the glutathione peroxidase 4 ( Gpx4 , the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species