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On the other hand, it has been demonstrated that beclin-1 can not only affect the regulation of autophagy as an autophagy regulator, but also affect the intake of cystine by combining with XCT to form the beclin-1/XCT complex, which leads to the inhibition of GPx4 synthesis and the increase of lipid peroxidation level (41)

(Gast et al., 1995)

Typically, animal OP models are acute, accompanied by drastic metabolic and hormonal changes, which differ significantly from the natural progression of age-related OP and PMO