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The expression of GhGPX1, GhGPX8 and GhGPX13 were also induced by ABA in leaves

Moreover, gut microbiota-derived metabolites, including D-amino acids and reactive oxygen species, contribute directly to glomerular and tubular dysfunction by promoting oxidative stress and insulin resistance (Nagase et al., 2022)

These compounds are known to play a role in glutathione production, which helps combat oxidative stress and supports metabolic processes [1][2]

However, high doses might cause side effects like gastrointestinal issues, allergic reactions, or skin rashes in some individuals

The evidence presented above notwithstanding, the 2020 guidelines for the prevention of CIPN issued by the American Society of Clinical Oncology do not yet endorse GM1 for prevention or treatment of CIPN, citing insufficient evidence (Loprinzi, Lacchetti 2020)