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When two or more independent drugs are combined, their effects add up, and the Bliss synergy score is 0 (39)

However, translating these findings faces challenges, including a narrow therapeutic window, patient heterogeneity, and the need to balance efficacy with safety concerning systemic iron and lipid metabolism

To allow broad clinical adoption, the field should establish unified data standards and a shared platform to facilitate multidisciplinary collaboration and communication [649,650,651]

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Elevated AGE-modified ApoB in sera of euglycemic, normolipidemic patients with atherosclerosis: relationship to tissue AGEs