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Our research findings demonstrate that natural products containing conjugated ,-unsaturated aldehydes can covalently modify AhpC and inhibit its activity, exhibiting distinct characteristics from other identified AhpC inhibitors

Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)

126 Administration of CoQ10 in doses ranging from 60mg500 mg/day significantly decreased production of inflammatory markers

doi: 10.1111/j.1742-7843.2006.pto_222.x Ultra-endurance exercise and oxidative damage: Implications for cardiovascular health

Alotaibi et al