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Nat Rev Immunol (2017) 17(4):26275

Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y

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In addition to the direct suppression of TYR catalytic activity, other methods for the disruption of melanogenesis include the post-transcriptional control of TYR, regulation of melanosome transfer and the suppression TYR transcription by suppressing upstream signaling pathways