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Glutathiones Antioxidant Properties A glutathione deficiency in the body is linked to cognitive decline, mitochondrial dysfunction, and other age-associated degeneration of health functions.* Recent research suggests that nutritional interventions, including amino acids, vitamins, minerals, and phytochemicals through diet and nutritional supplements, can help maintain an optimal circulating level of glutathione in the body.* 1 Glutathione exerts its antioxidant effects primarily through reduction , conjugation , and interaction with other antioxidants.* The following table highlights glutathiones antioxidant properties and how it eliminates toxins from the body and helps maintain the bodys antioxidant defense system.* 2 In addition, glutathione is involved in other beneficial cellular processes, such as protein folding, degradation of proteins with disulfide bonds, cell cycle regulation and proliferation, and beneficial cell death (apoptosis).* Although glutathione is a critical antioxidant and is endogenously produced by the body, its absorption is generally poor when taken orally as a supplement

Referenced in experimental models examining cellular communication and tissue-related pathways

Inhibition of oxidative metabolism to target cancer cell proliferation using various inhibitors has shown promise in both human and murine preclinical models 77

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5d), as did physiologically relevant concentrations 36 of reduced glutathione (GSH, Fig