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Further, unfolding the interesting structural and functional aspects of these enzymes in the last few years has qualified them as a potential drug target against various diseases

Dikic and Elazar, 2018)

10.1371/journal.pone.0017659 PLoS One 138 GrimmA.EckertA

including stability and impurities The history of use of the peptide The evidence for efficacy Any concerns about its safety Clinical need The most common objections to listing were inadequate clinical evidence of efficacy and safety, and determination that there were already FDA-approved products available to treat the specific disease(s)

10.1016/j.neuropharm.2008.08.006 125 LossC