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Nevertheless, most truncating variants falling within the regulatory domain did behave like null variants suggesting that our assay can still capture some large-effect variants in this domain

FIGURE 4 7 Ferroptosis-based treatment strategies for MM 7.1 Active ingredients of natural products The partial inhibition of cell death by Ferrostatin-1, Liproxstatin-1, or Deferoxamine, alongside evidence that natural product extracts induce MM cell death, implicates ferroptosis in MM cell demise

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Early lipid ROS accumulation downregulates CD86, CD40, and MHC II expression while reducing Interleukin-12(IL-12) and Interferon-(IFN-) secretion, impairing T cell activation ( The progression of ferroptosis in DCs follows a distinct temporal pattern