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Osteonecrosis: When injected into a joint, cortisone shots can cause osteonecrosis or the death of bone tissue

You are building tissue concentrations and assessing tolerance, not yet achieving therapeutic effects

A.FerrariE.SulzerD.CasellaL.et al (2014)

While IFN- can induce tumor cell killing, it can also promote tumor dormancy, edit tumor cells to cause immune evasion, and contribute to tumor relapse [113]

These may include prenatal exposures such as specific medications taken during pregnancy, like valproate, maternal infections, and exposure to pollutants like air pollution